| DATE | KO | OPPONENT | VENUE | SCORE |
|---|---|---|---|---|
| Fri 5 Aug | 15:00 | West Ham | Motspur Park | W 3-1 |
| Mon 15 Aug | 19:00 | Chelsea | Plough Lane | W 3-0 |
| Fri 19 Aug | 15:00 | Crystal Palace | Motspur Park | D 2-2 |
| Fri 26 Aug | 19:00 | Manchester United | Leigh Sports Village | D 2-2 |
| Mon 5 Sep | 15:00 | Wolves | Aggborough Stadium | D 1-1 |
| Sun 11 Sep | 12:00 | Arsenal | Motspur Park | ppd |
| Wed 14 Sep | 19:00 | Hull City | Craven Cottage | W 5-4 |
| Sat 17 Sep | 14:00 | Manchester City | Academy Stadium | L 1-0 |
| Fri 30 Sep | 19:00 | Everton | Motspur Park | W 2-0 |
| Wed 5 Oct | 19:00 | Valencia | Craven Cottage | D 0-0 |
| Mon 10 Oct | 19:00 | Leicester City | Leicester City Training Ground | W 7-0 |
| Tue 18 Oct | 19:00 | Celtic | Motspur Park | W 4-2 |
| Sat 22 Oct | 12:00 | Tottenham Hotspur | Hotspur Way | D 1-1 |
| Fri 28 Oct | 19:00 | Blackburn Rovers | Motspur Park | W 3-0 |
| Sun 6 Nov | 19:00 | Liverpool | Melwood | L 3-1 |
| Fri 11 Nov | 19:00 | Nottingham Forest | The Impact Arena | W 2-0 |
| Mon 28 Nov | 12:00 | Hull City | North Ferriby Utd FC | W 6-0 |
| Fri 9 Dec | 19:00 | Nottingham Forest | Motspur Park | |
| Fri 16 Dec | 19:00 | Charlton Athletic | Motspur Park | |
| Fri 6 Jan | 19:00 | Manchester United | Motspur Park | |
| Wed 11 Jan | 19:00 | FC Porto | Motspur Park | |
| Mon 16 Jan | 19:00 | Crystal Palace | Crystal Palace Training Ground | |
| Fri 20 Jan | 19:00 | Chelsea | Motspur Park | |
| Fri 27 Jan | 19:00 | Everton | Merseyrail Community Stadium | |
| Wed 1 Feb | 19:00 | Wolfsburg | Motspur Park | |
| Fri 10 Feb | 19:00 | West Ham | Rush Green | |
| Fri 17 Feb | 19:00 | Manchester City | Motspur Park | |
| Sun 26 Feb | 13:00 | Blackburn Rovers | Leyland County Ground | |
| Fri 3 Mar | 19:00 | Tottenham Hotspur | Motspur Park | |
| Mon 20 Mar | 19:00 | Brighton | AMEX Elite Performance Centre | |
| Fri 31 Mar | 19:30 | Leicester City | Motspur Park | |
| Fri 14 Apr | 19:00 | Wolves | Motspur Park | |
| Fri 21 Apr | 19:00 | Arsenal | Meadow Park | |
| Fri 28 Apr | 19:00 | Liverpool | Motspur Park | |
| Mon 8 May | 19:00 | Brighton | Motspur Park |
Home fixtures are shown in bold.
